منابع مشابه
Metagenomics
EditoriAL EditoriAL Estimates suggest that less than 1% of the microorganisms present in most habitats on Earth are culturable, 1 which means that our current view of the structural and functional diversity of the microbial world is severely limited and its vast emporium of potential medicines and useful industrial products lies virtually untapped. Furthermore, our historical reliance on cultur...
متن کاملIntegrated Metagenomics/Metaproteomics Reveals Human Host-Microbiota Signatures of Crohn's Disease
Crohn's disease (CD) is an inflammatory bowel disease of complex etiology, although dysbiosis of the gut microbiota has been implicated in chronic immune-mediated inflammation associated with CD. Here we combined shotgun metagenomic and metaproteomic approaches to identify potential functional signatures of CD in stool samples from six twin pairs that were either healthy, or that had CD in the ...
متن کاملAn integrated metagenomics pipeline for strain profiling reveals novel patterns of bacterial transmission and biogeography.
We present the Metagenomic Intra-species Diversity Analysis System (MIDAS), which is an integrated computational pipeline for quantifying bacterial species abundance and strain-level genomic variation, including gene content and single-nucleotide polymorphisms (SNPs), from shotgun metagenomes. Our method leverages a database of more than 30,000 bacterial reference genomes that we clustered into...
متن کاملVIP: an integrated pipeline for metagenomics of virus identification and discovery
Identification and discovery of viruses using next-generation sequencing technology is a fast-developing area with potential wide application in clinical diagnostics, public health monitoring and novel virus discovery. However, tremendous sequence data from NGS study has posed great challenge both in accuracy and velocity for application of NGS study. Here we describe VIP ("Virus Identification...
متن کاملIntegrated Metagenomics and Metatranscriptomics Analyses of Root-Associated Soil from Transgenic Switchgrass
The benefits of using transgenic switchgrass with decreased levels of caffeic acid 3-O-methyltransferase (COMT) as biomass feedstock have been clearly demonstrated. However, its effect on the soil microbial community has not been assessed. Here we report metagenomic and metatranscriptomic analyses of root-associated soil from COMT switchgrass compared with nontransgenic counterparts.
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2020
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-020-0542-0